BDBM432042 US10576064, Example I-283

SMILES CCOc1cccc(CN2[C@H]3CN(C(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]22C(=O)Nc3cc(Cl)ccc23)c2ccc(cc2)C(=O)NO)c1

InChI Key InChIKey=TXEOBRAQWREDST-VLWKUZPGSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 432042   

TargetE3 ubiquitin-protein ligase Mdm2 [23-127](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM432042(US10576064, Example I-283)
Affinity DataIC50:  4nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent