BDBM435239 N-(tert-butyl)-8-((2-(pyridin-3- yl)cyclopropanecarboxamido)methyl)- 5-(3-(trifluoromethoxy)phenyl)-3,4- dihydroisoquinoline-2(1H)- carboxamide (mixture of 4 isomers)::US10568876, Example 4

SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1CC1c1cccnc1)ccc2-c1cccc(OC(F)(F)F)c1

InChI Key InChIKey=VZVNAVWQXXDDAK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435239   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435239(N-(tert-butyl)-8-((2-(pyridin-3- yl)cyclopropaneca...)
Affinity DataIC50:  11.7nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent