BDBM435295 N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)-8-((2-(3- methyl-1,2,4-oxadiazol-5-yl) cyclopropanecarboxamido)methyl)-5-(3- (trifluoromethoxy)phenyl)-3,4- dihydroisoquinoline-2(1H)-carboxamide (mixture of 4 isomers)::US10568876, Example 58

SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC1(C)CCS(=O)(=O)C1

InChI Key InChIKey=RMJDMKMEZBRWJI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435295   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435295(N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)-8...)
Affinity DataIC50:  24nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent