BDBM435317 5-(3-(1H-pyrazol-1-yl)phenyl)-N-((S)-3- methyl-1,1-dioxidotetrahydrothiophen-3- yl)-8-((2-(3-methyl-1,2,4-oxadiazol-5- yl)cyclopropanecarboxamido)methyl)-3,4- dihydroisoquinoline-2(1H)-carboxamide (mixture of 4 isomers)::US10568876, Example 79

SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(c2)-n2cccn2)c2CCN(Cc12)C(=O)N[C@@]1(C)CCS(=O)(=O)C1

InChI Key InChIKey=AOQAWTVTZRXAHG-MPRDTSIKSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435317   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435317(5-(3-(1H-pyrazol-1-yl)phenyl)-N-((S)-3- methyl-1,1...)
Affinity DataIC50:  98nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent