BDBM443850 US10660877, Example 438

SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(Cc2cn[nH]c2)CC1)-c1cc(C)nc(C)c1

InChI Key InChIKey=NNHJMGVORBPPFP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 443850   

TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443850(US10660877, Example 438)
Affinity DataIC50:  1.20nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 9(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443850(US10660877, Example 438)
Affinity DataIC50:  69nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443850(US10660877, Example 438)
Affinity DataIC50:  3.10nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent