BDBM446557 (R)— or (S)—N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7-(4-fluorophenyl)-N4,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::US10669276, Example 46q

SMILES C[C@H]1CN(c2nc(Nc3ccc(c(F)c3)-n3cnc(C)c3)nc(Cl)c12)c1ccc(F)cc1

InChI Key InChIKey=GKNMZBKPHYTRGF-ZDUSSCGKSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 446557   

TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM446557((R)— or (S)—N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1...)
Affinity DataEC50:  7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent