BDBM446679 US10669289, Compound 86

SMILES OB(O)[C@H](Cc1coc2ccccc12)NC(=O)CN(C(=O)C=C)c1ccccc1F

InChI Key InChIKey=FPHLSYGVIFTDBA-IBGZPJMESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446679   

TargetProteasome subunit beta type-5(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM446679(US10669289, Compound 86)
Affinity DataIC50:  275nMAssay Description:Measurement of Beta5 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human constitutive proteasome (1.25 nM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM446679(US10669289, Compound 86)
Affinity DataIC50: <50nMAssay Description:Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immuno proteasome (0.25 nM) and s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent