BDBM450470 9H-Fluoren-9-ylmethyl 4-[3-[2-[(3,4-dichloro- phenyl)methyl- methylamino]-2- oxoethyl]-4- oxoquinazolin-6-yl] piperazine-1- carboxylate (intermediate A-6) and 1-(trifluoromethyl) cyclobutane-1- carboxylic acid ([CAS RN 277756-45- 3])::US10676446, Example 76

SMILES CN(Cc1ccc(Cl)c(Cl)c1)C(=O)Cn1cnc2ccc(cc2c1=O)N1CCN(CC1)C(=O)C1(CCC1)C(F)(F)F

InChI Key InChIKey=AEJQSYZWZCEYNZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450470   

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM450470(9H-Fluoren-9-ylmethyl 4-[3-[2-[(3,4-dichloro- phen...)
Affinity DataIC50:  10nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent