BDBM4877 1-(3-Methoxy-4-chloroanilino)-4-(4-pyridylmethyl)-phthalazine::CGP79787 Analog 62::CHEMBL75034::N-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

SMILES COc1cc(Nc2nnc(Cc3ccncc3)c3ccccc23)ccc1Cl

InChI Key InChIKey=CAGNWIMSXINYME-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 4877   

TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4877(1-(3-Methoxy-4-chloroanilino)-4-(4-pyridylmethyl)-...)
Affinity DataIC50:  260nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4877(1-(3-Methoxy-4-chloroanilino)-4-(4-pyridylmethyl)-...)
Affinity DataIC50:  140nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4877(1-(3-Methoxy-4-chloroanilino)-4-(4-pyridylmethyl)-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4877(1-(3-Methoxy-4-chloroanilino)-4-(4-pyridylmethyl)-...)
Affinity DataIC50:  3.50E+3nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4877(1-(3-Methoxy-4-chloroanilino)-4-(4-pyridylmethyl)-...)
Affinity DataIC50:  2.00E+3nMAssay Description:The autophosphorylation assay was performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified ov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed