BDBM493010 US10981906, Example 70::ethyl 4-(((1S,3S)-3-(2- cyanoacetoxy)cyclopentyl)(methyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate

SMILES CCOC(=O)c1cnc2[nH]ccc2c1N(C)[C@H]1CC[C@@H](C1)OC(=O)CC#N

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493010   

TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
Aclaris Therapeutics

US Patent
LigandPNGBDBM493010(US10981906, Example 70 | ethyl 4-(((1S,3S)-3-(2- c...)
Affinity DataIC50: <10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aclaris Therapeutics

US Patent
LigandPNGBDBM493010(US10981906, Example 70 | ethyl 4-(((1S,3S)-3-(2- c...)
Affinity DataIC50:  55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent