BDBM50014648 6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline; hydrobromide (o-methylcorypalline)::CHEMBL555787

SMILES COc1cc2CCN(C)Cc2cc1OC

InChI Key InChIKey=TXPPKWZEHFNZOE-UHFFFAOYSA-N

Data  13 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50014648   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  870nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK293 cell membranes after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  870nMAssay Description:Displacement of [3H]epibatidine from rat alpha4/beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of MAOA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  2.70E+4nMAssay Description:Compound was tested for inhibition against human placental Monoamine oxidase A (competitive inhibition was observed)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  2.90E+4nMAssay Description:Compounds were tested for inhibition against human liver Monoamine oxidase B (competitive inhibition was observed)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  2.90E+4nMAssay Description:Inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  4.67E+4nMAssay Description:Displacement of [3H]-serotonin from human SERT expressed in African green monkey COS7 cells after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  1.29E+5nMAssay Description:Displacement of [3H]-dopamine from human NET expressed in African green monkey COS7 cells after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  3.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha3/beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  3.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha4/beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  3.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK293 cell membranes after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  3.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nAChR expressed in HEK293 cell membranes after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi: >1.00E+7nMAssay Description:Displacement of [3H]-dopamine from human DAT expressed in African green monkey COS7 cells after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human alpha7 nAChR expressed in HEK293 cells co-expressing Ric-3/NACHO assessed as induction of calcium mobilization measured up ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataIC50:  1.00E+5nMAssay Description:Antagonist activity at rat alpha3beta4 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced current response measured up to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit beta-2/beta-4(Mus musculus)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataIC50:  1.20E+4nMAssay Description:Antagonist activity at mouse alpha4beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced current response measured up ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in HEK293 cells co-expressing Ric-3/NACHO assessed as inhibition of ACh-induced calcium mobilizat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit beta-2(Mus musculus)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataIC50:  1.20E+4nMAssay Description:Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014648(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Affinity DataIC50:  1.00E+5nMAssay Description:Antagonist activity at rat alpha3/beta4 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed