BDBM50015427 CHEMBL3265017

SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1OC

InChI Key InChIKey=YRFUVUYUKBPPHG-UHFFFAOYSA-N

Data  1 IC50  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50015427   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015427(CHEMBL3265017)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015427(CHEMBL3265017)
Affinity DataEC50:  919nMAssay Description:Inhibition of Syk in goat antihuman IgE-induced CD63 expression in human whole blood by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015427(CHEMBL3265017)
Affinity DataKd:  9nMAssay Description:Binding affinity to Syk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015427(CHEMBL3265017)
Affinity DataEC50:  24nMAssay Description:Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed