BDBM50022677 CHEMBL3298270::US9181261, 17
SMILES CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1
InChI Key InChIKey=JGYGLGXRSWCQPC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50022677
Affinity DataEC50: 119nMT: 2°CAssay Description:TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...More data for this Ligand-Target Pair
Affinity DataKd: 63nMAssay Description:Binding affinity to His-tagged TrkA (unknown origin) after 1 hr by SPR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of human TrkA expressed in human U2OS cells assessed as inhibition of NGF-induced maximum response after 1 hr by beta-galactosidase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 132nMAssay Description:Inhibition of phsophorylated TrkA (unknown origin) assessed as inhibition of fluorescently-labelled substrate phosphorylation by CALIPER enzymatic as...More data for this Ligand-Target Pair