BDBM50031518 CHEMBL3359145

SMILES Oc1ccc(cc1NC(=O)COc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)OCc1ccc(cc1)C1(N=N1)C(F)(F)F)C2)C(=O)OCC#C

InChI Key InChIKey=SGLAFTPYZYIWFY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50031518   

TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50031518(CHEMBL3359145)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of MDH2 (unknown origin) pre-incubated for 1 hr followed by malate and NAD+ additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50031518(CHEMBL3359145)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of HIF-1alpha in human HCT116 cells incubated for 12 hrs under hypoxic conditions by Western blotting and HRE-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed