BDBM50031740 CHEMBL3360357::US10206907, Compound 304

SMILES O=C(Nc1nc2cccc(-c3ccc(CNC4CCS(=O)(=O)C4)cc3)n2n1)C1CC1

InChI Key InChIKey=UABXGLFOIASIQY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50031740   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031740(CHEMBL3360357 | US10206907, Compound 304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of JAK2 in human whole blood assessed as inhibition of GM-CSF-induced pSTAT5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031740(CHEMBL3360357 | US10206907, Compound 304)
Affinity DataIC50:  6.15E+3nMAssay Description:Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1 [850-1154](Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM50031740(CHEMBL3360357 | US10206907, Compound 304)
Affinity DataIC50: <100nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM50031740(CHEMBL3360357 | US10206907, Compound 304)
Affinity DataIC50: <100nMAssay Description:Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031740(CHEMBL3360357 | US10206907, Compound 304)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed