BDBM50033548 6-[(2,5-Diethoxy-phenylamino)-methyl]-5,6,7,8-tetrahydro-quinazoline-2,4-diamine::CHEMBL120939

SMILES CCOc1ccc(OCC)c(NCC2CCc3nc(N)nc(N)c3C2)c1

InChI Key InChIKey=HGKWDWXLYOQMCF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50033548   

TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033548(6-[(2,5-Diethoxy-phenylamino)-methyl]-5,6,7,8-tetr...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033548(6-[(2,5-Diethoxy-phenylamino)-methyl]-5,6,7,8-tetr...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033548(6-[(2,5-Diethoxy-phenylamino)-methyl]-5,6,7,8-tetr...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033548(6-[(2,5-Diethoxy-phenylamino)-methyl]-5,6,7,8-tetr...)
Affinity DataIC50:  1.57E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033548(6-[(2,5-Diethoxy-phenylamino)-methyl]-5,6,7,8-tetr...)
Affinity DataIC50:  140nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033548(6-[(2,5-Diethoxy-phenylamino)-methyl]-5,6,7,8-tetr...)
Affinity DataIC50:  1.57E+3nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed