BDBM50037479 (6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol::CHEMBL326103

SMILES CCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21

InChI Key InChIKey=ZMAYVLNGIHEQKO-RMZCCROUSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50037479   

TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037479((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  16nMAssay Description:Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037479((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  16nMAssay Description:Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037479((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  32nMAssay Description:Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037479((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  158nMAssay Description:Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037479((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  1.66E+4nMAssay Description:Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50037479((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Opioid receptors with [3H]naloxone binding in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50037479((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Opioid receptors binding by inhibiting specific [3H]naloxone binding by 50% in the presence of 100 mM NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed