BDBM50041175 5-[(3,4,5-Trimethoxy-phenylamino)-methyl]-furo[2,3-d]pyrimidine-2,4-diamine::CHEMBL16950

SMILES COc1cc(NCc2coc3nc(N)nc(N)c23)cc(OC)c1OC

InChI Key InChIKey=PQRAIAZIJGMIFB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50041175   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041175(5-[(3,4,5-Trimethoxy-phenylamino)-methyl]-furo[2,3...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibitory concentration of the compound for DHFR in Pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041175(5-[(3,4,5-Trimethoxy-phenylamino)-methyl]-furo[2,3...)
Affinity DataIC50: >3.70E+4nMAssay Description:Inhibitory concentration of the compound for DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041175(5-[(3,4,5-Trimethoxy-phenylamino)-methyl]-furo[2,3...)
Affinity DataIC50: >2.60E+4nMAssay Description:Inhibitory concentration of the compound for DHFR in recombinant humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041175(5-[(3,4,5-Trimethoxy-phenylamino)-methyl]-furo[2,3...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory concentration of the compound for DHFR in Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041175(5-[(3,4,5-Trimethoxy-phenylamino)-methyl]-furo[2,3...)
Affinity DataIC50: >2.60E+4nMAssay Description:Inhibitory concentration of the compound for DHFR in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed