BDBM50048961 4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy-biphenyl-3-carboxylic acid::4'-(2-Amino-3-mercapto-propylamino)-2'-methoxy-biphenyl-3-carboxylic acid 12(FTI-281)::CHEMBL301667

SMILES COc1cc(NC[C@@H](N)CS)ccc1-c1cccc(c1)C(O)=O

InChI Key InChIKey=IXIKCENTAPEJEA-CYBMUJFWSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50048961   

TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50048961(4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...)
Affinity DataIC50:  37nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048961(4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048961(4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...)
Affinity DataIC50:  40nMAssay Description:Inhibition of the FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048961(4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...)
Affinity DataIC50:  4.36E+4nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048961(4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed