BDBM50049026 5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-spiro[2.4]hepta-4,6-diene::CHEMBL89429

SMILES CS(=O)(=O)c1ccc(cc1)C1=CC2(CC2)C=C1c1ccc(F)cc1

InChI Key InChIKey=CJAWPKAYKMKKAD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50049026   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049026(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda

Curated by ChEMBL
LigandPNGBDBM50049026(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda

Curated by ChEMBL
LigandPNGBDBM50049026(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  25.7nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda

Curated by ChEMBL
LigandPNGBDBM50049026(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed