BDBM50061877 3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]octane::CHEMBL11776

SMILES Fc1ccc(cc1)C(OC1CC2CCC(C1)N2)c1ccc(F)cc1

InChI Key InChIKey=ZBKITZYQNFJNIF-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50061877   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061877(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3....)
Affinity DataKi:  9.70nMAssay Description:In vitro inhibition of dopamine uptake in rat tissue, was determined using [3H]-DAU as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061877(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3....)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]-WIN- 35, 428 from the dopamine transporter in rat caudate putamen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061877(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3....)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]WIN-35428 from the dopamine transporter in rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061877(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3....)
Affinity DataKi:  156nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M1 sites of ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061877(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3....)
Affinity DataKi:  203nMAssay Description:Binding affinity at Muscarinic acetylcholine receptor M1 in Rat brain homogenate by [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061877(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3....)
Affinity DataKi:  2.10E+3nMAssay Description:Compound is evaluated for binding to Serotonin transporter using [3H]-Citalopram as radioligand in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061877(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3....)
Affinity DataKi: >8.00E+3nMAssay Description:Compound was evaluated for binding to Norepinephrine Transporter (NET).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed