BDBM50066260 CHEMBL3400435

SMILES COCCCOc1cc(ccc1OC)C(=O)N(C[C@@H]1CNC[C@H]1NCc1ccc2ccccc2c1)C(C)C

InChI Key InChIKey=XZJFCCNTHXFRPO-WUFINQPMSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50066260   

TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant human renin by fluorescence based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant human renin by fluorescence based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50:  75nMAssay Description:Inhibition of recombinant human renin by fluorescence based FRET assay in presence of plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human pepsin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using DBF fluorometric substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam fluorometric substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066260(CHEMBL3400435)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human pepsin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed