BDBM50072665 CHEMBL3410040

SMILES Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccccc4Cl)cc3)c12

InChI Key InChIKey=ZYMWDMDUXLTZON-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50072665   

TargetLIM domain kinase 1(Rattus norvegicus)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072665(CHEMBL3410040)
Affinity DataIC50:  420nMAssay Description:Inhibition of Limk1 in rat A7r5 cells assessed as reduction in cofilin phosphorylation by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072665(CHEMBL3410040)
Affinity DataIC50:  4.39E+3nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072665(CHEMBL3410040)
Affinity DataIC50:  3.34E+3nMAssay Description:Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072665(CHEMBL3410040)
Affinity DataIC50:  58nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed