BDBM50076127 (S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carbonyl]-amino}-4-methyl-pentanoic acid::CHEMBL26923

SMILES CC(C)C[C@H](NC(=O)c1ccc(OCCn2ccnc2)cc1-c1ccccc1)C(O)=O

InChI Key InChIKey=CNHFDLPFXKHRKU-QFIPXVFZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50076127   

LigandPNGBDBM50076127((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076127((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076127((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Affinity DataIC50:  303nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed