BDBM50076222 (1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]pyridazine-1-carboxylic acid [(S)-1-(benzothiazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL282830

SMILES NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCN2CC[C@@](N)(Cc3ccccc3)CN12)C(=O)c1nc2ccccc2s1

InChI Key InChIKey=WQDOEYAJPUSQCH-RXYILKCJSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50076222   

TargetSerine protease 1(Bos taurus (bovine))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076222((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.640nMAssay Description:Inhibitory concentration of the compound against trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076222((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.650nMAssay Description:Inhibitory concentration of the compound against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076222((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataIC50:  270nMAssay Description:Inhibitory concentration of the compound against coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076222((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataIC50:  495nMAssay Description:Inhibitory concentration of the compound against Tissue type plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076222((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataIC50:  270nMAssay Description:Inhibitory concentration of the compound against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076222((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataIC50:  600nMAssay Description:Inhibitory concentration of the compound against Urokinase-type plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076222((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataIC50:  415nMAssay Description:Inhibitory concentration of the compound against plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed