BDBM50076305 (4R,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one::CHEMBL34015

SMILES C[C@H]1C(=O)C(C)(C)Nc2ccc3-c4ccccc4O[C@@H](c4ccc(Cl)cc4)c3c12

InChI Key InChIKey=FOPLNUAISVOILB-FATZIPQQSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50076305   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076305((4R,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-1,2,4,...)
Affinity DataKi:  21nMAssay Description:Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076305((4R,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-1,2,4,...)
Affinity DataKi:  698nMAssay Description:Binding affinity against baculovirus expressed human androgen receptor (hAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076305((4R,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-1,2,4,...)
Affinity DataKi:  913nMAssay Description:Binding affinity against baculovirus expressed human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076305((4R,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-1,2,4,...)
Affinity DataEC50:  23nMAssay Description:Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076305((4R,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-1,2,4,...)
Affinity DataEC50:  5.30nMAssay Description:Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed