BDBM50090175 CHEMBL3581554::US9216988, 17

SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2ccc(cc2)C(C)(C)C)c(F)c1

InChI Key InChIKey=GLMBGUOOQNUUNB-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50090175   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50090175(CHEMBL3581554 | US9216988, 17)
Affinity DataIC50:  18nMpH: 7.4Assay Description:On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50090175(CHEMBL3581554 | US9216988, 17)
Affinity DataEC50:  120nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50090175(CHEMBL3581554 | US9216988, 17)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed