BDBM50092350 (5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-dichloro-pyridin-4-yl)-amine::5-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-6-methoxyphthalazin-1-amine::CHEMBL70903

SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)nncc2c1OC1CCCC1

InChI Key InChIKey=KBKFKOUQHDZZOS-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50092350   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50092350((5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-...)
Affinity DataKi:  95nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50092350((5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-...)
Affinity DataIC50:  59nMAssay Description:In vitro inhibitory concentration against phosphodiesterase 4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50092350((5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-...)
Affinity DataIC50:  59nMAssay Description:Inhibition of Phosphodiesterase 4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50092350((5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50092350((5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-...)
Affinity DataIC50:  59nMAssay Description:Inhibitory concentration against phosphodiesterase 4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed