BDBM50094479 CHEMBL3590225

SMILES CN(C)CC(=O)N1CCC(CC1)c1cc(-c2cnc(N)c(n2)-n2nnc3ccccc23)n(C)n1

InChI Key InChIKey=GDCXQTWGESMOSP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50094479   

LigandPNGBDBM50094479(CHEMBL3590225)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2/ATP as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50094479(CHEMBL3590225)
Affinity DataIC50:  91nMAssay Description:Inhibition of PI3Kalpha in human BT474 cells assessed as inhibition of Akt phosphorylation at Tyr-308 after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50094479(CHEMBL3590225)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of PI3Kbeta in human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation at Ser-473 after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50094479(CHEMBL3590225)
Affinity DataIC50:  380nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2/ATP as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50094479(CHEMBL3590225)
Affinity DataIC50:  90nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed