BDBM50100002 2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL418036

SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccccc3Cl)c2)CC1=O

InChI Key InChIKey=UNMKLZBYJNBEEK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50100002   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100002(2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)
Affinity DataIC50:  41nMAssay Description:Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100002(2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)
Affinity DataIC50:  700nMAssay Description:In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100002(2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)
Affinity DataIC50:  7.00E+3nMAssay Description:In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed