BDBM50105838 FENOBAM

SMILES CN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1

InChI Key InChIKey=DWPQODZAOSWNHB-UHFFFAOYSA-N

Data  6 KI  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50105838   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataKi:  32nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataKi:  33nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataKi:  162nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataKi:  162nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataKi:  162nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
University Of Modena And Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataKi:  313nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))TBA
LigandPNGBDBM50105838(FENOBAM)
Affinity DataIC50:  3.31E+3nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataIC50:  36nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataIC50:  36nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
University Of Modena And Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataIC50:  51nMAssay Description:Displacement of [3H]-MPEP from rat mGlu5 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataIC50:  51nMAssay Description:Displacement of [3H]-MPEP from human mGlu5 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataIC50:  36nMAssay Description:Negative allosteric modulatory activity at human cloned mGluR5 receptor expressed in CHO-T-Rex cells assessed as inhibiton of quisqualate-induced cal...More data for this Ligand-Target Pair