BDBM50108622 CHEMBL3597964::US9403813, 111

SMILES COc1cc(C(=O)N2CC[C@H]2c2noc(n2)-c2cccc(Cl)c2OC)c(cc1C)-n1nccn1

InChI Key InChIKey=JTRBZPNNQMWVFP-KRWDZBQOSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50108622   

TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50108622(CHEMBL3597964 | US9403813, 111)
Affinity DataIC50:  0.700nMT: 2°CAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50108622(CHEMBL3597964 | US9403813, 111)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at human orexin-2 receptor expressed in CHO cells assessed as inhibition of human orexin-A-induced calcium flux preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50108622(CHEMBL3597964 | US9403813, 111)
Affinity DataIC50:  82nMAssay Description:Antagonist activity at human orexin-1 receptor expressed in CHO cells assessed as inhibition of human orexin-A-induced calcium flux preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50108622(CHEMBL3597964 | US9403813, 111)
Affinity DataIC50:  82nMT: 2°CAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In DepthDetails US Patent