BDBM50109866 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-pyridin-3-ylmethyl-piperidine-1-carboxamidine::CHEMBL157570

SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(Br)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](-[#7]-[#6]-c2cccnc2)=[#7]C#N)c1

InChI Key InChIKey=MSYWKAUBOIFIPF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50109866   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50109866(4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohep...)
Affinity DataIC50:  15nMAssay Description:FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed