BDBM50112245 CHEMBL3608741::US10030025, Compound 11::US10836768, Cpd no 11::US11731974, Compound 11::US9422299, 11::US9987274, Compound 11

SMILES Cc1nsc(n1)-c1nnc2[C@@H](CCO)N(CCn12)C(=O)c1ccc(F)cc1

InChI Key InChIKey=SZEYAOKHLPDWFZ-CYBMUJFWSA-N

Data  18 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50112245   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  5.00E+4nMAssay Description:The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  79nMAssay Description:Antagonist activity against human recombinant NK3R expressed in CHO cells by aequorin functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

US Patent
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  73nMAssay Description:Changes in intracellular calcium levels are a recognized indicator of G protein-coupled receptor activity. The efficacy of compounds of the invention...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Euroscreen

US Patent
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  5.00E+4nMAssay Description:The human ether-a-go-go related gene (hERG) encodes the inward rectifying voltage gated potassium channel in the heart (Igr) which is involved in car...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Euroscreen

US Patent
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  5.00E+4nMAssay Description:The human ether-a-go-go related gene (hERG) encodes the inward rectifying voltage gated potassium channel in the heart (IKr) which is involved in car...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

US Patent
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  73nMAssay Description:Changes in intracellular calcium levels are a recognized indicator of G protein-coupled receptor activity. The efficacy of compounds of the invention...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Euroscreen

US Patent
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  7.70E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

US Patent
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50:  73nMAssay Description:Chinese Hamster Ovary recombinant cells expressing the human NK-3 receptor and a construct that encodes the photoprotein apoaequorin were used for th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50112245(CHEMBL3608741 | US10030025, Compound 11 | US108367...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed