BDBM50113033 (2R,5R)-5-Hydroxy-1-[4-(3-trifluoromethyl-benzyloxy)-benzenesulfonyl]-piperidine-2-carboxylic acid hydroxyamide::CHEMBL28351

SMILES ONC(=O)[C@H]1CC[C@@H](O)CN1S(=O)(=O)c1ccc(OCc2cccc(c2)C(F)(F)F)cc1

InChI Key InChIKey=HTWOMTYWAUKKSB-CRAIPNDOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50113033   

LigandPNGBDBM50113033((2R,5R)-5-Hydroxy-1-[4-(3-trifluoromethyl-benzylox...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113033((2R,5R)-5-Hydroxy-1-[4-(3-trifluoromethyl-benzylox...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113033((2R,5R)-5-Hydroxy-1-[4-(3-trifluoromethyl-benzylox...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibitory concentration of the compound against Matrix metalloproteinase-1 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed