BDBM50122415 1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl)-cyclohexanol::CHEMBL100875

SMILES OC1(CCC(CC1)N1CCN(Cc2ccccc2)CC1)c1ccc2OCOc2c1

InChI Key InChIKey=QWOWPFGONZKUAH-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50122415   

Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration of the compound required against 5-HT uptake in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1B receptor in rat striatum using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1C receptor in bovine choroid plexus using [3H]-mesulergineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  410nMAssay Description:Inhibitory concentration required against Alpha-2 adrenergic receptor in rat cortex [3H]clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory concentration of the compound required against Dopamine receptor D2 in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory concentration required against 5-hydroxytryptamine 2 receptor in rat cortex using [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  700nMAssay Description:Inhibitory concentration required against alpha-1 adrenergic receptor in rat cortex using [3H]-WB- 4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed