BDBM50124609 5-Allyl-2,2,4-trimethyl-10-prop-2-ynyloxy-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL8360

SMILES CC1=CC(C)(C)Nc2ccc-3c(C(CC=C)Oc4cccc(OCC#C)c-34)c12

InChI Key InChIKey=SNHVWFHHKLONNR-UHFFFAOYSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50124609   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124609(5-Allyl-2,2,4-trimethyl-10-prop-2-ynyloxy-2,5-dihy...)
Affinity DataKi:  4.20nMAssay Description:Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]-Dexamethasone as radioligand in SF-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124609(5-Allyl-2,2,4-trimethyl-10-prop-2-ynyloxy-2,5-dihy...)
Affinity DataEC50: >300nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124609(5-Allyl-2,2,4-trimethyl-10-prop-2-ynyloxy-2,5-dihy...)
Affinity DataEC50:  270nMAssay Description:Binding affinity towards aldosterone receptor (Mineralocorticoid receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed