BDBM50150338 CHEMBL181604::N-{3-[(2,4-Difluoro-benzyl)-(4-phenoxy-benzyl)-amino]-2-methyl-phenyl}-methanesulfonamide

SMILES Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccc(Oc2ccccc2)cc1)Cc1ccc(F)cc1F

InChI Key InChIKey=JFMRDJSHFJJWFS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50150338   

TargetGlucocorticoid receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150338(CHEMBL181604 | N-{3-[(2,4-Difluoro-benzyl)-(4-phen...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of dexamethasone-induced glucocorticoid receptor mediated tyrosine aminotransferase in rat hepatocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150338(CHEMBL181604 | N-{3-[(2,4-Difluoro-benzyl)-(4-phen...)
Affinity DataIC50:  385nMAssay Description:Inhibition of dexamethasone-induced glucocorticoid receptor mediated alkaline phosphatase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150338(CHEMBL181604 | N-{3-[(2,4-Difluoro-benzyl)-(4-phen...)
Affinity DataIC50:  95nMAssay Description:Inhibition of [3H]dexamethasone binding to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150338(CHEMBL181604 | N-{3-[(2,4-Difluoro-benzyl)-(4-phen...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of glucocorticoid receptor Dexamethasone response in reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150338(CHEMBL181604 | N-{3-[(2,4-Difluoro-benzyl)-(4-phen...)
Affinity DataIC50:  21nMAssay Description:Inhibition of [3H]dexamethasone binding to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed