BDBM50151526 CHEMBL363097::N-(4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-phenyl)-acetamide::US8637528, OM956

SMILES CC(=O)Nc1ccc(cc1)-c1nn(C)\c(=N\C2CCCCC2)s1

InChI Key InChIKey=HMLIQWYFUWNFED-ZPHPHTNESA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50151526   

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM50151526(CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-met...)
Affinity DataIC50:  140nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM50151526(CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-met...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151526(CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-met...)
Affinity DataIC50:  3.43E+4nMAssay Description:Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM50151526(CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-met...)
Affinity DataIC50:  144nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
In DepthDetails US Patent