BDBM50156686 CHEMBL3794389::US11485707, Example 23

SMILES Cc1ccc(C(=O)OCc2ccc(cc2)C(CN)C(=O)Nc2ccc3cnccc3c2)c(C)c1

InChI Key InChIKey=OURRXQUGYQRVML-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50156686   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156686(CHEMBL3794389 | US11485707, Example 23)
Affinity DataKi:  4.20nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Fochon Pharmaceuticals

US Patent
LigandPNGBDBM50156686(CHEMBL3794389 | US11485707, Example 23)
Affinity DataIC50:  21nMAssay Description:Table 2: ROCK-I(h) kinase assays were conducted using the KinaseProfiler™ service of Eurofins Pharma Discovery Services UK Limited. ROCK-I(h) was inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Fochon Pharmaceuticals

US Patent
LigandPNGBDBM50156686(CHEMBL3794389 | US11485707, Example 23)
Affinity DataIC50:  18nMAssay Description:Table 2: ROCK-I(h) kinase assays were conducted using the KinaseProfiler™ service of Eurofins Pharma Discovery Services UK Limited. ROCK-I(h) was inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Fochon Pharmaceuticals

US Patent
LigandPNGBDBM50156686(CHEMBL3794389 | US11485707, Example 23)
Affinity DataIC50:  21nMAssay Description:Table 2: ROCK-I(h) kinase assays were conducted using the KinaseProfiler™ service of Eurofins Pharma Discovery Services UK Limited. ROCK-I(h) was inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Fochon Pharmaceuticals

US Patent
LigandPNGBDBM50156686(CHEMBL3794389 | US11485707, Example 23)
Affinity DataIC50:  17nMAssay Description:Table 2: ROCK-I(h) kinase assays were conducted using the KinaseProfiler™ service of Eurofins Pharma Discovery Services UK Limited. ROCK-I(h) was inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Fochon Pharmaceuticals

US Patent
LigandPNGBDBM50156686(CHEMBL3794389 | US11485707, Example 23)
Affinity DataIC50:  17nMAssay Description:Table 2: ROCK-I(h) kinase assays were conducted using the KinaseProfiler™ service of Eurofins Pharma Discovery Services UK Limited. ROCK-I(h) was inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Fochon Pharmaceuticals

US Patent
LigandPNGBDBM50156686(CHEMBL3794389 | US11485707, Example 23)
Affinity DataIC50:  39nMAssay Description:Table 2: ROCK-I(h) kinase assays were conducted using the KinaseProfiler™ service of Eurofins Pharma Discovery Services UK Limited. ROCK-I(h) was inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Fochon Pharmaceuticals

US Patent
LigandPNGBDBM50156686(CHEMBL3794389 | US11485707, Example 23)
Affinity DataIC50:  27nMAssay Description:Table 2: ROCK-I(h) kinase assays were conducted using the KinaseProfiler™ service of Eurofins Pharma Discovery Services UK Limited. ROCK-I(h) was inc...More data for this Ligand-Target Pair
In DepthDetails US Patent