BDBM50159114 CHEMBL179234::Cyclopropyl-[2-(4-cyclopropyl-piperazin-1-yl)-quinolin-6-yl]-methanone

SMILES O=C(C1CC1)c1ccc2nc(ccc2c1)N1CCN(CC1)C1CC1

InChI Key InChIKey=REZSROOERNUDJU-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50159114   

TargetHistamine H3 receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50159114(CHEMBL179234 | Cyclopropyl-[2-(4-cyclopropyl-piper...)
Affinity DataKi:  1.80nMAssay Description:Antagonist potency against human H3 receptor in GTPgamma[S]-AssayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50159114(CHEMBL179234 | Cyclopropyl-[2-(4-cyclopropyl-piper...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibiton of [3H]-ketanserin binding to human 5-HT2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50159114(CHEMBL179234 | Cyclopropyl-[2-(4-cyclopropyl-piper...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibiton of [3H]-histamine binding to human H4 histamine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50159114(CHEMBL179234 | Cyclopropyl-[2-(4-cyclopropyl-piper...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]-pyrilamine binding to human H1 histamine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50159114(CHEMBL179234 | Cyclopropyl-[2-(4-cyclopropyl-piper...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [125I]-aminopotentidine binding to human H2 histamine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed