BDBM50162013 1-(2,6-Difluoro-benzyl)-3-((R)-2-dimethylamino-2-phenyl-ethyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione::CHEMBL179429

SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N(C)C)c2ccccc2)c1=O

InChI Key InChIKey=NAKAWVWXVKWSQY-DEOSSOPVSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50162013   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162013(1-(2,6-Difluoro-benzyl)-3-((R)-2-dimethylamino-2-p...)
Affinity DataKi:  6.5nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162013(1-(2,6-Difluoro-benzyl)-3-((R)-2-dimethylamino-2-p...)
Affinity DataKi:  120nMAssay Description:Binding affinity for Monkey gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162013(1-(2,6-Difluoro-benzyl)-3-((R)-2-dimethylamino-2-p...)
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity for Rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162013(1-(2,6-Difluoro-benzyl)-3-((R)-2-dimethylamino-2-p...)
Affinity DataIC50:  49nMAssay Description:Inhibition of Human gonadotropin-releasing hormone receptor stimulated calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed