BDBM50164236 6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine; compound with methanesulfonic acid::CHEMBL363831::CHEMBL404377

SMILES CC(C)S(=O)(=O)n1c(N)nc2ccc(cc12)-c1[nH]c(nc1-c1ccc(F)cc1F)C(C)(C)C

InChI Key InChIKey=KIPJKVFPFLSCTH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50164236   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50164236(6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50164236(6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...)
Affinity DataIC50:  26.2nMAssay Description:Inhibition of mouse p38alpha in anisomycin-stimulated RAW 264.7 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50164236(6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human recombinant p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed