BDBM50168400 2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-N-methoxy-benzamide::CHEMBL370515

SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F

InChI Key InChIKey=PFPXVMRFOYULPT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50168400   

TargetFibroblast growth factor receptor 1/2/3/4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168400(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168400(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168400(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human fibroblast growth factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1/2/3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168400(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed