BDBM501778 4-[6-(4-aminopiperidin-1-yl)-4- methyl-3-(4-methylphenyl)-5-oxo- 4, 5-dihydropyrazin-2- yl]benzonitrile::US11028066, Example 16
SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N
InChI Key InChIKey=AAYMLFXVNGDTKW-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 501778
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene Quanticel Research
US Patent
Celgene Quanticel Research
US Patent
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene Quanticel Research
US Patent
Celgene Quanticel Research
US Patent
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene Quanticel Research
US Patent
Celgene Quanticel Research
US Patent
Affinity DataIC50: 47nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair