BDBM50183965 6-chloro-4-(1-(naphthalen-2-ylmethyl)piperidin-4-ylamino)-1-(pyridin-2-ylmethyl)quinolin-2(1H)-one::CHEMBL377084

SMILES Clc1ccc2n(Cc3ccccn3)c(=O)cc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c2c1

InChI Key InChIKey=SHCFFLWIRMAQPN-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50183965   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183965(6-chloro-4-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)
Affinity DataKi:  88nMAssay Description:Binding affinity to hERG stably transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183965(6-chloro-4-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [125I]MCH from MCHr1 expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183965(6-chloro-4-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)
Affinity DataIC50:  55nMAssay Description:Inhibition of MCH-mediated calcium release in whole IMR32 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed