BDBM50191588 (2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate::Antimycin A1::Antipiricullin::CHEMBL211501::Fintrol::Virosin::antimycin A::antimycin A1b

SMILES CCCCCC[C@@H]1[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O

InChI Key InChIKey=UIFFUZWRFRDZJC-SBOOETFBSA-N

Data  2 KI  8 IC50

PDB links: 6 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50191588   

TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataKi:  3.82E+3nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataKi:  3.82E+3nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataIC50:  5.96E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial(Septoria tritici)
Fmc Stine Research Center

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Septoria nodorum succinate dehydrogenase by FMET2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataIC50: >1.33E+5nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (fumarate)(Saccharomyces cerevisiae)
Harvard School Of Public Health

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Saccharomyces cerevisiae DHODMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Harvard School Of Public Health

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum DHODMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial(Septoria tritici)
Fmc Stine Research Center

Curated by ChEMBL
LigandPNGBDBM50191588((2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Septoria nodorum succinate dehydrogenase and Qi site of mitochondrial respiratory chain complex 3 by FMET2-3 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed