BDBM50196634 CHEMBL3976949::US10167270, Compound 11b

SMILES Cc1cncc(c1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1

InChI Key InChIKey=SKNLOHJCCVGXLC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50196634   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196634(CHEMBL3976949 | US10167270, Compound 11b)
Affinity DataIC50:  12.5nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196634(CHEMBL3976949 | US10167270, Compound 11b)
Affinity DataIC50:  13nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed