BDBM50215998 CHEMBL247141::cis-tert-butyl 3-(4-((2-methylquinolin-4-yl)methoxy)benzamido)-4-(5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyrrolidine-1-carboxylate

SMILES Cc1cc(COc2ccc(cc2)C(=O)N[C@@H]2CN(C[C@@H]2c2n[nH]c(=S)[nH]2)C(=O)OC(C)(C)C)c2ccccc2n1

InChI Key InChIKey=WUGZBWFREMAISJ-LADGPHEKSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50215998   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215998(CHEMBL247141 | cis-tert-butyl 3-(4-((2-methylquino...)
Affinity DataKi: >3.33E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215998(CHEMBL247141 | cis-tert-butyl 3-(4-((2-methylquino...)
Affinity DataKi:  3.56E+3nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215998(CHEMBL247141 | cis-tert-butyl 3-(4-((2-methylquino...)
Affinity DataKi: >4.50E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215998(CHEMBL247141 | cis-tert-butyl 3-(4-((2-methylquino...)
Affinity DataKi: >5.03E+3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215998(CHEMBL247141 | cis-tert-butyl 3-(4-((2-methylquino...)
Affinity DataKi: >6.37E+3nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50215998(CHEMBL247141 | cis-tert-butyl 3-(4-((2-methylquino...)
Affinity DataIC50:  14nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed