BDBM50222727 (5S,11S,13aR)-5,8,8-trimethyl-11-[5-(pyridin-2-yldisulfanyl)-pentyl]-decahydro-3a,6,9,12-tetraaza-cyclopetacyclododecene-4,7,10,13-tetraone::CHEMBL238596::cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-)

SMILES C[C@@H]1NC(=O)C(C)(C)NC(=O)[C@H](CCCCCSSc2ccccn2)NC(=O)[C@H]2CCCN2C1=O

InChI Key InChIKey=SNOZDSAKXKVXTD-OKZBNKHCSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50222727   

TargetHistone deacetylase 6(Mus musculus)
Graduate School Of Life Science And Systems Engineering

Curated by ChEMBL
LigandPNGBDBM50222727((5S,11S,13aR)-5,8,8-trimethyl-11-[5-(pyridin-2-yld...)
Affinity DataIC50:  43nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering

Curated by ChEMBL
LigandPNGBDBM50222727((5S,11S,13aR)-5,8,8-trimethyl-11-[5-(pyridin-2-yld...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human HDAC1 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering

Curated by ChEMBL
LigandPNGBDBM50222727((5S,11S,13aR)-5,8,8-trimethyl-11-[5-(pyridin-2-yld...)
Affinity DataIC50:  94nMAssay Description:Inhibition of HDAC1 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering

Curated by ChEMBL
LigandPNGBDBM50222727((5S,11S,13aR)-5,8,8-trimethyl-11-[5-(pyridin-2-yld...)
Affinity DataIC50:  430nMAssay Description:Inhibition of HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering

Curated by ChEMBL
LigandPNGBDBM50222727((5S,11S,13aR)-5,8,8-trimethyl-11-[5-(pyridin-2-yld...)
Affinity DataIC50:  52nMAssay Description:Inhibition of HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering

Curated by ChEMBL
LigandPNGBDBM50222727((5S,11S,13aR)-5,8,8-trimethyl-11-[5-(pyridin-2-yld...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed